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See the manufacturer’s labeled week-by-week dose escalation for semaglutide or tirzepatide laid out on a calendar. Pick the drug, your start date, and how many weeks you hold each step. It is a reference reproduction of the label, not a prescription — your clinician may use a different schedule. For the plasma-level curve, see the half-life calculator.
| Step | Starts | Dose (mg) | Units * |
|---|---|---|---|
| Weeks 1–4 | — | 2.5 | — |
| Weeks 5–8 | — | 5 | — |
| Weeks 9–12 | — | 7.5 | — |
| Weeks 13–16 | — | 10 | — |
| Weeks 17–20 | — | 12.5 | — |
| Week 21+ | — | 15 | — |
This reproduces the manufacturer's labeled escalation schedule for Tirzepatide (Zepbound): the lowest dose is a starting dose, each step is held at least 4 weeks, and the top dose is the maintenance dose. The label increases only if the previous dose is tolerated. Units would use a U-100 syringe at your entered concentration. This is a reference reproduction of the label — NOT a prescription or personalized advice. Your prescriber may use a different schedule; hold or slow escalation per the label and your clinician.
Frequently asked questions
What is the standard GLP-1 titration schedule?
For weight management, the semaglutide (Wegovy) label escalates through 0.25, 0.5, 1.0, 1.7, and 2.4 mg once weekly, and tirzepatide (Zepbound) through 2.5, 5, 7.5, 10, 12.5, and 15 mg once weekly, holding each step at least four weeks before increasing. The top dose is the maintenance dose.
Why is each step held for at least four weeks?
The labels raise the dose only after the previous dose has been tolerated for at least four weeks, which gives the gut time to adjust and helps limit nausea and other side effects. Some people stay longer at a step; the builder lets you set the weeks per step.
Can I go faster or slower than the schedule?
The builder lets you change the weeks per step so you can see a slower schedule, but the labeled minimum is four weeks per step and dose increases depend on tolerating the current dose. Any change to your own schedule is a decision for you and your prescriber, not this tool.
How do I turn a dose into units to draw?
Enter the concentration of your reconstituted solution and the builder adds a units column: units equal the dose divided by the concentration, times 100, on a U-100 syringe. Leave concentration blank to see the milligram schedule only.
Is this medical advice?
No. It reproduces the manufacturer’s labeled schedule for reference and does the calendar and unit arithmetic. It is not a prescription, does not account for your individual response, and does not replace your prescriber. Confirm any schedule with the product label and a clinician.